大鼠孕期诱导产生的H-Y抗体及其向胎儿的传递。
Pregnancy-induced H-Y antibodies and their transmission to the foetus in rats.
作者信息
Shalev A
出版信息
Immunology. 1980 Feb;39(2):285-9.
Rats of DA strain produce H-Y antibodies in response to the stimulation by their male foetuses. About 52% of the rats following a single or multiple pregnancy and 45.5% of litters (female offspring) had detectable levels of H-Y antibodies in their blood serum. The presence of H-Y antibodies did not appear to be correlated with the stage of parity or the number of male foetuses the female bore. H-Y antibodies were detected in the serum of a 27 day post-partum female and her 27 day old female offspring but not in any of the male offspring. It is suggested that H-Y antibodies are transmitted to the foetus in utero and through the milk (colostrum). The possible significance of these findings in relation to the ontogenic role of H-Y antigen is discussed.
DA 品系的大鼠在受到雄性胎儿刺激后会产生 H-Y 抗体。单次或多次怀孕后的大鼠中，约 52%以及 45.5%的窝仔（雌性后代）血清中可检测到 H-Y 抗体。H-Y 抗体的存在似乎与产次阶段或雌性所怀雄性胎儿的数量无关。在产后 27 天的雌性大鼠及其 27 天大的雌性后代血清中检测到了 H-Y 抗体，但在任何雄性后代中均未检测到。研究表明，H-Y 抗体可通过子宫内和乳汁（初乳）传递给胎儿。本文讨论了这些发现与 H-Y 抗原个体发生作用相关的可能意义。
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