TLCK或氨茶碱可消除活化巨噬细胞对细胞内病原体的抑制或杀伤作用。
Inhibition or killing of an intracellular pathogen by activated macrophages is abrogated by TLCK or aminophylline.
作者信息
McLeod R, Remington J S
出版信息
Immunology. 1980 Apr;39(4):599-605.
Abstract
Agents that are known to inhibit certain metabolic pathways or cell functions were evaluated to determine their effects on the capacity of activated macrophages to inhibit or kill obligate intracellular pathogens. Tosyllysine chloromethyl ketone (TLCK) and aminophylline abrogate inhibition or killing of Toxoplasma gondii by activated macrophages.
摘要
已知能抑制某些代谢途径或细胞功能的试剂被评估，以确定它们对活化巨噬细胞抑制或杀死专性细胞内病原体能力的影响。甲苯磺酰赖氨酸氯甲基酮（TLCK）和氨茶碱可消除活化巨噬细胞对刚地弓形虫的抑制或杀伤作用。
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3
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