Faragó E, Kiss I J, Mihóczy L
Int J Clin Pharmacol Ther Toxicol. 1980 Mar;18(3):128-32.
Antibiotic sensitivity of bacteria cultured from 1020 pulmonological, medical and surgical cases was determined. Inhibitory effect on the bacterial growth was observed most frequently with sisomicin among the antibiotics of aminoglycoside type. Sisomicin levels were studied in the serum and lung tissue in 20 cases of pulmonary operations. Fifty to ninety minutes subsequent to an intramuscular administration of 1 mg sisomicin per 1 kg body weight, the serum levels amounted to 4.0 mcg/ml, whereas the apparently healthy, the inflamed and tumourous parts of the removed lung tissue contained 2.2, 1.2 and 0.2 mcg/g. The serum level remained unchanged even after 110-150 min, when the lung tissue levels were 3.0, 1.5 and 2.1 mcg/g. The sisomicin concentrations found in the lung tissue are of bactericid effect only against a part of the bacteria studied. This fact emphasizes the importance of exact indication and use of doses of sisomicin.
对1020例肺科、内科和外科病例培养出的细菌进行了抗生素敏感性测定。在氨基糖苷类抗生素中，西索米星对细菌生长的抑制作用最为常见。对20例肺部手术患者的血清和肺组织中的西索米星水平进行了研究。每1千克体重肌肉注射1毫克西索米星后50至90分钟，血清水平达到4.0微克/毫升，而切除的肺组织中明显健康、发炎和肿瘤部分分别含有2.2、1.2和0.2微克/克。即使在110 - 150分钟后血清水平仍保持不变，此时肺组织水平分别为3.0、1.5和2.1微克/克。在肺组织中发现的西索米星浓度仅对部分所研究的细菌具有杀菌作用。这一事实强调了准确指征和使用西索米星剂量的重要性。
