Mandell R B, Farrell R
Invest Ophthalmol Vis Sci. 1980 Jun;19(6):697-702.
Corneas of 28 human subjects were exposed to oxygen partial pressures, in a gas goggle, of either 6.9, 17.1, or 22.2 mm Hg, and the corneal swelling was measured by pachometry for 4 hr. Following an initial rise, the swelling stabilized after about 3 hr; in many subjects it was reversed, indicating an adaptation process. The average corneal swelling after 4 hr for the three oxygen partial pressures was 5.07%, 2.13%, and 1.66%, respectively. The average minimum oxygen requirement to prevent corneal swelling was at least 23 mm Hg and varied significantly among individuals. The variations in swelling responses were large enough to explain clinical differences in edema of patients wearing oxygen-permeable contact lenses, in the absence of adequate tear pumping.
28名人类受试者的角膜在气体眼罩中分别暴露于6.9、17.1或22.2毫米汞柱的氧分压下，通过角膜厚度测量法测量角膜肿胀情况，持续4小时。在最初的上升之后，肿胀在大约3小时后稳定下来；在许多受试者中，肿胀出现了逆转，这表明存在适应过程。三种氧分压下4小时后的平均角膜肿胀率分别为5.07%、2.13%和1.66%。防止角膜肿胀的平均最低氧需求至少为23毫米汞柱，且个体之间差异显著。在没有足够泪液泵作用的情况下，肿胀反应的差异大到足以解释佩戴透氧隐形眼镜患者水肿的临床差异。
