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从兔嗜碱性粒细胞中分离出的血小板活化因子被鉴定为乙酰甘油醚磷酸胆碱。

Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.

作者信息

Hanahan D J, Demopoulos C A, Liehr J, Pinckard R N

出版信息

J Biol Chem. 1980 Jun 25;255(12):5514-6.

PMID:7380824
Abstract

Platelet activating factor obtained from antigen-stimulated rabbit buffy coat leukocytes containing 10% IgE-sensitized basophils was shown by gas-liquid chromatographic and mass spectrometric analysis of products after acetolysis and by base and acid hydrolysis to be acetyl-alkylglyceryl phosphorylcholine. The alkyl side chains were composed of octadecyl (greater than 90%) and hexadecyl (less than 10%) residues.

摘要

通过对乙酰解产物进行气液色谱和质谱分析以及通过碱水解和酸水解表明，从含有10% IgE致敏嗜碱性粒细胞的抗原刺激兔血沉棕黄层白细胞中获得的血小板活化因子是乙酰烷基甘油磷酰胆碱。烷基侧链由十八烷基（大于90%）和十六烷基（小于10%）残基组成。

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