Gm 同种异型的定量研究。V. 一个伴有低丙种球蛋白血症先证者的家族中潜在 Gm 同种异型和缺陷 Gm 基因的同时存在。

Quantitative studies of Gm allotypes. V. Simultaneous presence of latent Gm allotypes and deficient Gm genes in a family with hypogammaglobulinaemic probands.

作者信息

Salier J P, Rivat L, Daveau M, Lefranc G, Breton P, de Menibus C H, Henocq A, Fudenberg H H

出版信息

J Immunogenet. 1980 Apr;7(2):123-35. doi: 10.1111/j.1744-313x.1980.tb00714.x.

DOI:10.1111/j.1744-313x.1980.tb00714.x

Abstract

A study of Gm allotypes in a Caucasoid family with hypogammaglobulinaemic probands, showed qualitative (unexpected or lacking Gm allotypes) and quantitative (increased or decreased Gm contents) abnormalities in many relatives. Part of these observations can be most probably accounted for by inheritance of a GM1,17; 5,28 haplotype, not described in Caucasians yet, and by an in vivo expression of latent Gm genes.

摘要

一项对患有低丙种球蛋白血症先证者的高加索家族中Gm同种异型的研究表明，许多亲属存在定性（意外的或缺乏Gm同种异型）和定量（Gm含量增加或减少）异常。这些观察结果部分可能最有可能是由一种尚未在高加索人中描述的GM1,17; 5,28单倍型的遗传以及潜在Gm基因的体内表达所致。