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[森林涅涅茨人的种群结构。IV. 免疫球蛋白别型以及Cγ1基因无效表达的Gm单倍型的浓度和起源]

[Population structure of the forest Nentsi. IV. Immunoglobulin allotypes and the concentration and origin of Gm haplotypes with a null expression of the C gammal gene].

作者信息

Osipova L P, Sukernik R I

出版信息

Genetika. 1984 Jan;20(1):155-65.

PMID:6421655
Abstract

Serum blood samples from 796 of the total 1600 Forest Nentsi, the members of the isolate in the north-western part of Siberia were tested for the G1m (z, a, x, f), G2m (n), G3m (g, b0, b1, b3, b5, s, t) and Km (1) antigens. Significant heterogeneity in local Gm haplotype and Km1 allele frequencies has been found. The frequencies of "deleted" Gm (-; n; b) and Gm (-;..; g) haplotypes were found to be equal 0,020 and 0,004, respectively. When segregation disturbances for the Gm locus were inspected in 102 families, no apparent deviations from Mendelian expectations occurred. Blent, Oriental-Caucasian origin of Forest Nentsi has been confirmed by the presence of "Northern Oriental" Gm (za; b035st) and "Caucasian" Gm (f; b0135) markers showing the frequency of 0.199 and 136, respectively.

摘要

在西伯利亚西北部与世隔绝的1600名森林涅涅茨人(Forest Nentsi)中,抽取了796人的血清血样,检测了G1m(z、a、x、f)、G2m(n)、G3m(g、b0、b1、b3、b5、s、t)和Km(1)抗原。发现当地Gm单倍型和Km1等位基因频率存在显著异质性。发现“缺失型”Gm(-; n; b)和Gm(-;..; g)单倍型的频率分别为0.020和0.004。在102个家庭中检查Gm基因座的分离干扰时,未发现明显偏离孟德尔预期的情况。通过“北方东方型”Gm(za; b035st)和“高加索型”Gm(f; b0135)标记的存在证实了森林涅涅茨人具有混合的东方 - 高加索血统,其频率分别为0.199和136。 (注:原文中“136”这个频率数据可能有误,推测可能是0.136,翻译时保留了原文数据。)

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