Moser M, Hinghofer-Szalkay H, Kenner T, Holzer H
J Clin Chem Clin Biochem. 1980 Apr;18(4):233-6.
The colloid osmotic pressure of plasma is a clinically and physiologically important variable. Like the plasma density, it is a function of the total concentration of plasma proteins. Thus, plasma colloid osmotic pressure can be determined from measurement of the plasma density. Minor variations are caused by variations of the albumin-globulin ratio and, much less frequently, by increased concentration of low molecular substances in the plasma. The direct measurement of the colloid osmotic pressure is a time consuming and complex procedure. The determination of the plasma density using the mechanical oscillator technique is a simple and fast procedure. From our results we were able to derive and prove the applicability of an equation which permits the calculation of the colloid osmotic pressure from the measured values of the plasma density. The plasma volume needed for the measurement is 0.2 ml, the measuring time amounts to a few seconds.
血浆胶体渗透压是一个在临床和生理方面都很重要的变量。与血浆密度一样，它是血浆蛋白总浓度的函数。因此，血浆胶体渗透压可通过测量血浆密度来确定。微小的变化是由白蛋白 - 球蛋白比例的变化引起的，而由血浆中低分子物质浓度增加引起的情况则少得多。直接测量胶体渗透压是一个耗时且复杂的过程。使用机械振荡器技术测定血浆密度是一个简单快速的过程。根据我们的结果，我们能够推导并证明一个方程的适用性，该方程允许根据血浆密度的测量值计算胶体渗透压。测量所需的血浆体积为0.2毫升，测量时间仅需几秒钟。
