Wieland D M, Wu J, Brown L E, Mangner T J, Swanson D P, Beierwaltes W H
J Nucl Med. 1980 Apr;21(4):349-53.
The tissue distributions of three radioiodinated neuron-blocking agents have been determined in dogs. Iodine-125-labeled meta- and para-iodobenzylguanidines show a striking affinity for, and retention in, the adrenal medulla. Peak concentrations of the two isomers exceed those of previously reported adrenophilic compounds. High myocardial concentrations were also observed at early time intervals. Images of the dog's adrenal medullae have been obtained with para [131I]iodobenzylguanidine.
已测定三种放射性碘化神经阻滞剂在犬体内的组织分布。碘-125标记的间碘苄胍和对碘苄胍对肾上腺髓质表现出显著的亲和力并能在其中潴留。这两种异构体的峰值浓度超过了先前报道的亲肾上腺化合物。在早期时间间隔也观察到高心肌浓度。已用对[131I]碘苄胍获得了犬肾上腺髓质的图像。
