线性二室开放模型外周室的蓄积
Accumulation in the peripheral compartment of a linear two-compartment open model.
作者信息
Gonda I, Harpur E S
出版信息
J Pharmacokinet Biopharm. 1980 Feb;8(1):99-104. doi: 10.1007/BF01059451.
PMID:7381694
Abstract
Accumulation factors for the peripheral compartment in a two-compartment open model are derived. These expressions are contrasted with some previously published statements concerning drug accumulation. The utility of the new indices of accumulation is illustrated by reference to studies of gentamicin tissue.uptake and its proposed relation to nephrotoxicity.
摘要
推导了二室开放模型中外周室的蓄积因子。这些表达式与先前发表的一些关于药物蓄积的论述进行了对比。通过参考庆大霉素组织摄取及其与肾毒性的拟议关系的研究，说明了新的蓄积指数的实用性。
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