具有抗着床作用的前列腺素类似物。2. α链的修饰。
Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain.
作者信息
Hayashi M, Arai Y, Wakatsuka H, Kawamura M, Konishi Y, Tsuda T, Matsumoto K
出版信息
J Med Chem. 1980 May;23(5):525-35. doi: 10.1021/jm00179a011.
PMID:7381852
Abstract
Additional double bonds were introduced into the alpha chain in 16-phenoxy-, 16-(3-chlorophenoxy)-, 16-[3-(tri-fluoromethyl)phenoxy]-, and 16-(4-chlorophenoxy)-17,18,19,20-tetranorprostaglandins which have antinidatory effects. Of these analogues, the delta 3-cis-delta 5 analogues 23b is 1200 times more potent than prostaglandin F2 alpha in antinidatory effect in the rat and more potent than any other known prostaglandin analogues.
摘要
在具有抗着床作用的16-苯氧基-、16-(3-氯苯氧基)-、16-[3-(三氟甲基)苯氧基]-和16-(4-氯苯氧基)-17,18,19,20-四去甲前列腺素的α链中引入了额外的双键。在这些类似物中，δ3-顺式-δ5类似物23b在大鼠抗着床作用方面比前列腺素F2α强1200倍，且比任何其他已知的前列腺素类似物都更有效。
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