大鼠长期摄入氧化锰：血液学影响。

Chronic manganese oxide ingestion in rats: hematological effects.

作者信息

Carter S D, Hein J F, Rehnberg G L, Laskey J W

出版信息

J Toxicol Environ Health. 1980 Jan;6(1):207-16. doi: 10.1080/15287398009529843.

PMID:7381971

Abstract

Hematological values were studied in Long Evans rats after chronic exposure to manganese oxide (Mn3O4). Data were obtained at selected ages from the P0 through the F2 generation. Effects of exposure to Mn3O4 during Fe deficiency were determined by placing half of the animals on a low-Fe diet (20 mg/kg) while the other half were maintained on a normal-Fe diet (240 mg/kg). Animals treated with Mn3O4 and maintained on a normal-Fe diet showed little variation from controls through 100 d of age. However, animals (24-100 d of age) maintained on a low-Fe diet and receiving Mn treatment during the prenatal and postnatal periods developed microcytic anemia. Irrespective of the dietary Fe level, serum creatinine levels decreased in the groups receiving 400 and 1100 ppm Mn while serum Ca and P levels increased in the group receiving 1100 ppm Mn at 100 d of age. Serum values for lactate dehydrogenase, alkaline phosphatase (100 d of age), and serum glutamic-oxaloacetic transaminase (224 d of age) were elevated for all animals on low-Fe diets. Globulin, albumin (100 d of age), and glucose (224 d of age) levels were depressed in all low-Fe groups.

摘要

对长期暴露于氧化锰（Mn3O4）的长 Evans 大鼠的血液学指标进行了研究。在选定的年龄（从 P0 代到 F2 代）获取数据。通过将一半动物置于低铁饮食（20 毫克/千克），另一半维持在正常铁饮食（240 毫克/千克），来确定缺铁期间暴露于 Mn3O4 的影响。用 Mn3O4 处理并维持在正常铁饮食的动物，直到 100 日龄时与对照组相比几乎没有变化。然而，在产前和产后期间维持低铁饮食并接受锰处理的动物（24 - 100 日龄）出现了小细胞性贫血。无论饮食中铁的水平如何，接受 400 和 1100 ppm 锰的组中血清肌酐水平下降，而在 100 日龄时接受 1100 ppm 锰的组中血清钙和磷水平升高。所有低铁饮食组动物的乳酸脱氢酶、碱性磷酸酶（100 日龄）和血清谷草转氨酶（224 日龄）的血清值均升高。所有低铁组的球蛋白、白蛋白（100 日龄）和葡萄糖（224 日龄）水平均降低。