Rehnberg G L, Hein J F, Carter S D, Laskey J W
J Toxicol Environ Health. 1980 Jan;6(1):217-26. doi: 10.1080/15287398009529844.
Mn accumulation was evaluated in selected tissues of preweanling rats dosed daily with particulate Mn3O4. Significant findings include a high rate of Mn accumulation in the preweanling rat; a Mn dose-related acceleration of postpartum liver iron depletion; a Mn dose-related depression in red blood cells, hematocrit, hemoglobin, body weight, and survival by 21 d postpartum; and a Mn distribution in tissues with liver greater than brain greater than or equal to kidney greater than testes at 18-21 d of age.
对每日经口给予颗粒状四氧化三锰的断奶前大鼠的选定组织中的锰蓄积情况进行了评估。重要发现包括：断奶前大鼠体内锰蓄积率较高；产后肝脏铁消耗的加速与锰剂量相关；产后21天时，红细胞、血细胞比容、血红蛋白、体重和存活率下降与锰剂量相关；在18 - 21日龄时，组织中的锰分布情况为肝脏＞脑≥肾脏＞睾丸。
