Painter R B
Mutat Res. 1980 May;70(3):337-41. doi: 10.1016/0027-5107(80)90023-8.
A model for the production of sister-chromatid exchanges is presented, based on the idea that double-strand breaks are generated at junctions between a completely duplicated replicon cluster and a partially duplicated replicon cluster. Agents that induce absolute blocks to DNA fork displacement will cause this condition to persist longer than normal, whereas agents that inhibit initiation of whole clusters will rarely cause it at all. During the blunt-end repair of the double-strand breaks, sister-chromatod exchange would be initiated when daughter strands of a duplicated cluster recombine with the parental strands of the partially replicated cluster. When the latter finishes replication, sister-chromatid exchange would be completed.
基于双链断裂在完全复制的复制子簇与部分复制的复制子簇之间的连接处产生这一观点，提出了一种姐妹染色单体交换产生的模型。诱导DNA叉移位绝对阻滞的试剂会使这种情况持续的时间比正常情况更长，而抑制整个簇起始的试剂则很少会导致这种情况。在双链断裂的平端修复过程中，当复制簇的子链与部分复制簇的亲代链重组时，姐妹染色单体交换就会开始。当后者完成复制时，姐妹染色单体交换就会完成。
