Di Nola F, Eandi M, Capra E, Soranzo M L, Bosio G, Bramato C, Salassa B, Andrini L, Robecchi G A
Minerva Med. 1980 May 26;71(21):1515-24.
The results of a pharmacokinetic and clinical study of cephamandol naphate indicated that the drug quickly reaches high plasma concentration after both i.m. and i.v. bolus administration. Urinary excretion of the biologically active form is as much as 84--90% of the total dose and mostly takes place in the first 6 hr. The therapeutic response was good: clinical cure in 90%, marked improvement in 6.6%, no change in 3.3%.
头孢孟多酯钠的药代动力学和临床研究结果表明，该药物经肌内注射和静脉推注后均能迅速达到较高的血浆浓度。生物活性形式的尿液排泄量高达总剂量的84% - 90%，且大多在最初6小时内发生。治疗反应良好：临床治愈率为90%，显著改善率为6.6%，无变化率为3.3%。
