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矽肺与支气管癌(作者译)

[Silicosis and bronchial cancer (author's transl)].

作者信息

Maillard J M

出版信息

Poumon Coeur. 1980 Jan-Feb;36(1):41-8.

PMID:7383960
Abstract
  1. At world level, silicosis does not predispose to bronchial cancer. But from region to region, the relationship silicosis-cancer varies and depends on factors other than silica. 2. It has not been proved that silica is cancerigen in laboratory animal. 3. Subjects exposed to silica can also be exposed in other circumstances to known carcerigen agents (ionizing radiations, iron oxides, arsenic, exhaust gases of explosion engins). In Switzerland, it is possible that miners in galeries could breath low concentrations of radon and benzopyrene. But it is very difficult to know to what extent these potential risks are involved. 4. Bronchial carcinoma in silicotic patients does not own any characteristics. It is quite similar to that found in the remainder of the population. On the other hand, its diagnosis and treatment are more difficult because of the presence of silicosis. 5. The fortuitous association of silicosis and bronchial cancer is due to overlapping of the profiles of both diseases. The increasing life span of the silicotic patient and the high frequency of bronchial cancer explain why this association is not more exceptional.
摘要
  1. 在全球范围内,矽肺不会诱发支气管癌。但在不同地区,矽肺与癌症的关系各不相同,且取决于二氧化硅以外的其他因素。2. 尚未在实验动物中证明二氧化硅具有致癌性。3. 接触二氧化硅的人在其他情况下也可能接触到已知的致癌物质(电离辐射、氧化铁、砷、内燃机废气)。在瑞士,坑道中的矿工有可能吸入低浓度的氡和苯并芘。但很难知道这些潜在风险在多大程度上起作用。4. 矽肺患者的支气管癌没有任何特征。它与其他人群中发现的支气管癌非常相似。另一方面,由于矽肺的存在,其诊断和治疗更加困难。5. 矽肺和支气管癌的偶然关联是由于两种疾病的特征重叠。矽肺患者寿命的延长和支气管癌的高发病率解释了为什么这种关联并不罕见。

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