含手性吡咯烷基团的氧震颤素拮抗剂的立体选择性。
Stereoselectivity of oxotremorine antagonists containing a chiral pyrrolidine group.
作者信息
Ringdahl B, Dahlbom R
出版信息
Experientia. 1978 Oct 15;34(10):1334-5. doi: 10.1007/BF01981455.
PMID:738410
Abstract
Oxotremorine (Ia) and its succinimide analogue (IIa) have been substituted in the pyrrolidine ring with a methyl group in the 2- or 3-positions. The compounds are oxotremorine antagonists. The 2-methyl-substituted enantiomers show stereoselectivity, the S-isomers being the most active.
摘要
氧化震颤素（Ia）及其琥珀酰亚胺类似物（IIa）在吡咯烷环的2-位或3-位被甲基取代。这些化合物是氧化震颤素拮抗剂。2-甲基取代的对映体表现出立体选择性，S-异构体活性最强。
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