一些含有两个手性中心的氧代震颤素拮抗剂的立体选择性
Stereoselectivity of some oxotremorine antagonists containing two chiral centres.
作者信息
Ringdahl B, Resul B, Dahlbom R
出版信息
J Pharm Pharmacol. 1979 Dec;31(12):837-9. doi: 10.1111/j.2042-7158.1979.tb13676.x.
Abstract
The stereoisomers of some analogues of oxotremorine containing two chiral centres, one in the 1-position of the butynyl chas are oxotremorine antagonists. They show a marked stereoselectivity, which depends mainly on the configuration of the chiral centre in the butynyl chain and to a lesser extent on the configuration of that in the pyrrolidine ring.
摘要
一些含有两个手性中心的氧代震颤素类似物的立体异构体是氧代震颤素拮抗剂，其中一个手性中心在丁炔基链的1位。它们表现出显著的立体选择性，这主要取决于丁炔基链上手性中心的构型，在较小程度上取决于吡咯烷环上手性中心的构型。
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