Pazdernik T L, Corbett M D
Pharmacology. 1980;20(2):87-94. doi: 10.1159/000137348.
Oral administration of chloramphenicol did not significantly alter the early stage of chronic hypoplastic marrow failure induced by busulfan. Chloramphenicol reduction products were most suppressive to antigen-reactive cells detected by the Mishell-Dutton plaque-forming cell assay. This reduction in immunocompetence may be an important parameter in the initial phases of the etiology of chloramphenicol-induced aplastic anemia.
口服氯霉素不会显著改变白消安诱导的慢性再生低下性骨髓衰竭的早期阶段。氯霉素还原产物对通过米舍尔-达顿空斑形成细胞试验检测到的抗原反应性细胞具有最强的抑制作用。免疫能力的这种降低可能是氯霉素诱导的再生障碍性贫血病因学初始阶段的一个重要参数。
