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氟哌啶醇与氯美噻唑联合治疗震颤谵妄(作者译)

[Combination therapy of delirium tremens with haloperidol and clomethiazol (author's transl)].

作者信息

Finzen C, Kruse G

出版信息

Psychiatr Prax. 1980 Feb;7(1):50-6.

PMID:7384303
Abstract

Despite the successes achieved by modern distraneurinomonotherapy, treatment of delirium tremens remains full of complications and high-risk problem. Basing on theoretical considerations regarding the delirium tremens as a form of psychosis, the additional application of a neuroleptic with an antipsychotic action is suggested to achieve a specific treatment, exercising a direct influence both on the psychotic and on the neurovegetative signs of alcoholic delirium. Experiences collected with a combination treatment extending over two years with haloperidol IV and ch clomethiazol oral, point to a decrease in the incidence rate of delirium, a milder course of the delirium itself, and a corresponding decrease in associated complications. This should stimulate further systematic and statistically safe investigations in this field.

摘要

尽管现代戒酒硫单一疗法取得了成功,但震颤谵妄的治疗仍然充满并发症和高风险问题。基于将震颤谵妄视为一种精神病形式的理论考虑,建议额外应用具有抗精神病作用的抗精神病药物以实现特异性治疗,对酒精性谵妄的精神病性症状和神经植物性症状均产生直接影响。通过静脉注射氟哌啶醇和口服氯美噻唑进行为期两年的联合治疗所收集的经验表明,谵妄的发病率有所降低,谵妄本身的病程较轻,相关并发症也相应减少。这应该会促使在该领域进行进一步系统且具有统计学安全性的研究。

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