• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

放线菌素D或嘌呤霉素对雌性大鼠肝脏中由睾酮增强的微粒体睾酮羟化酶活性的影响。

Effect of actinomycin D or puromycin on microsomal testosterone hydroxylase activity enhanced by testosterone in female rat liver.

作者信息

Sato N, Ota M, Obara K

出版信息

Experientia. 1978 Oct 15;34(10):1375-6. doi: 10.1007/BF01981484.

DOI:10.1007/BF01981484
PMID:738434
Abstract

The injection of testosterone propionate for 4 successive days into female rats resulted in an increase of the in vitro conversion of the hydroxylated testosterones from testosterone by the hepatic microsomal fraction, but no change in the content of microsomal cytochrome P-450 occurred. Actinomycin D or puromycin, which was administered for 4 days with injections of testosterone propionate, prevented the enzyme induction.

摘要

连续4天给雌性大鼠注射丙酸睾酮，导致肝微粒体部分对睾酮羟基化睾酮的体外转化率增加，但微粒体细胞色素P - 450的含量没有变化。与丙酸睾酮注射一起给药4天的放线菌素D或嘌呤霉素可阻止酶诱导。

相似文献

1
Effect of actinomycin D or puromycin on microsomal testosterone hydroxylase activity enhanced by testosterone in female rat liver.放线菌素D或嘌呤霉素对雌性大鼠肝脏中由睾酮增强的微粒体睾酮羟化酶活性的影响。
Experientia. 1978 Oct 15;34(10):1375-6. doi: 10.1007/BF01981484.
2
The effects of actinomycin D and puromycin on the induction of the cytosol enzymes involved in the androgen metabolism by testosterone in female rat liver.放线菌素D和嘌呤霉素对雌性大鼠肝脏中睾酮诱导的参与雄激素代谢的胞质酶的影响。
Endokrinologie. 1977 Feb;69(1):1-10.
3
Impact of tamoxifen on peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11, cytochrome P450 3A2, and steroid 5 alpha-reductase.他莫昔芬对大鼠青春期前肝脏细胞色素P450 2C11、细胞色素P450 3A2和类固醇5α-还原酶雄激素印记的影响。
Biochem Pharmacol. 1996 Feb 9;51(3):357-68. doi: 10.1016/0006-2952(95)02191-4.
4
Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation.大鼠肝脏细胞色素P450 2C11和类固醇5α-还原酶的青春期雄激素印记：翻译前调控及其对微粒体药物激活的影响
J Pharmacol Exp Ther. 1996 Sep;278(3):1383-91.
5
Flumecinol, a novel inducer of testosterone 16 alpha-hydroxylation in male rats.氟美西诺，一种雄性大鼠睾酮16α-羟基化的新型诱导剂。
Xenobiotica. 1990 Jul;20(7):689-97. doi: 10.3109/00498259009046885.
6
Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme.人肝微粒体类固醇代谢：主要微粒体类固醇激素6β-羟化酶细胞色素P-450酶的鉴定。
Arch Biochem Biophys. 1988 Jun;263(2):424-36. doi: 10.1016/0003-9861(88)90655-8.
7
Imprinting of hepatic microsomal cytochrome P-450 enzyme activities and cytochrome P-450IIC11 by peripubertal administration of testosterone in female rats.青春期雌性大鼠围青春期给予睾酮对肝脏微粒体细胞色素P-450酶活性及细胞色素P-450IIC11的印记作用。
Mol Pharmacol. 1992 May;41(5):981-8.
8
Spectral changes in liver microsomal cytochrome P-450 from benzanthracene-treated normal and partially hepatectomized rats.苯并蒽处理的正常大鼠和部分肝切除大鼠肝脏微粒体细胞色素P-450的光谱变化
Chem Biol Interact. 1974 Apr;8(4):253-9. doi: 10.1016/0009-2797(74)90033-7.
9
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）通过抑制细胞色素P450 2C11信使核糖核酸水平来调节大鼠肝微粒体中环磷酰胺和异环磷酰胺的活化。
Drug Metab Dispos. 1994 Sep-Oct;22(5):673-9.
10
Involvement of testosterone in the induction of hepatic microsomal cytochrome P-450 2B1/2 (P-450 2B1/2) by 1-benzylimidazole in male and female rats: sex-differentiated induction of P-450 2B1/2 species.睾酮在1-苄基咪唑对雄性和雌性大鼠肝微粒体细胞色素P-450 2B1/2（P-450 2B1/2）诱导中的作用：P-450 2B1/2亚型的性别差异诱导
Biochim Biophys Acta. 1994 May 25;1200(1):11-8. doi: 10.1016/0304-4165(94)90021-3.

引用本文的文献

1
Estradiol treatment reduces a cytosol androgen binding protein in male rat liver.雌二醇治疗可降低雄性大鼠肝脏中的一种胞质雄激素结合蛋白。
Experientia. 1980 Jul 15;36(7):877-8. doi: 10.1007/BF01978627.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
J Biol Chem. 1964 Jul;239:2370-8.
3
Sex difference in rate of ring A reduction of delta 4-3-keto-steroids in vitro by rat liver.大鼠肝脏体外对δ4-3-酮类固醇A环还原速率的性别差异。
Endocrinology. 1958 Dec;63(6):887-902. doi: 10.1210/endo-63-6-887.
4
Effect of androgen and estrogen on the hydroxylation of steroid hormones by rat liver microsomes.
Endocrinol Jpn. 1969 Dec;16(6):653-63. doi: 10.1507/endocrj1954.16.653.
5
Sex differences in metabolism of testosterone by rat liver.
J Biochem. 1972 Jul;72(1):11-20. doi: 10.1093/oxfordjournals.jbchem.a129875.
6
Effects of testosterone and estradiol in vivo on hepatic cortisol metabolism in vitro.睾酮和雌二醇在体内对肝脏皮质醇体外代谢的影响。
Proc Soc Exp Biol Med. 1973 Jan;142(1):54-7. doi: 10.3181/00379727-142-36956.
7
Metabolism in vitro of (4-14C) testosterone by liver homogenates of normal and carbon tetrachloride injured rats.正常大鼠和四氯化碳损伤大鼠肝脏匀浆对（4-¹⁴C）睾酮的体外代谢
Tohoku J Exp Med. 1969 Jul;98(3):281-8. doi: 10.1620/tjem.98.281.
8
[Sexually differentiated and sexually undifferentiated 3alpha- and 3beta-hydroxysteroid dehydrogenase activities and their intracellular localization in rat liver].[大鼠肝脏中性别分化和未分化的3α-和3β-羟基类固醇脱氢酶活性及其细胞内定位]
Hoppe Seylers Z Physiol Chem. 1973 May;354(5):507-13.
9
Delta4-3 beta-hydroxysteroid dehydrogenase activity in rat liver. Intracellular distribution and sex dependency.大鼠肝脏中的△4-3β-羟基类固醇脱氢酶活性。细胞内分布及性别依赖性。
Eur J Biochem. 1974 Mar 1;42(2):561-6. doi: 10.1111/j.1432-1033.1974.tb03371.x.
10
The hypophysis in the regulation of androgen and oestrogen dependent enzyme activities of steroid hormone metabolism in rat liver cytosol.垂体对大鼠肝细胞溶胶中甾体激素代谢的雄激素和雌激素依赖性酶活性的调节作用。
Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):127-34. doi: 10.1515/bchm2.1975.356.1.127.