Christie D P
Radiology. 1980 Jul;136(1):85-90. doi: 10.1148/radiology.136.1.7384528.
Painful, crippling deformities in Tanzanian children from an area of endemic fluorosis are reported. Excessive fluoride ingestion in pregnant women may possibly poison and alter enzyme and hormonal systems in the fetus causing disturbances to osteoid formation and mineralization. Knock-knees, bowlegs, and saber shins develop when walking begins. Combinations of osteomalacia, osteoporosis, and osteosclerosis result in a spectrum of bone changes from an early age. Male hormones, and dietary and genetic deficiencies may aggravate individual response of actively growing bones. Some radiographic changes suggestive of rickets, hyperparathyroidism and thalassemia were observed.
据报道，在坦桑尼亚一个地方性氟中毒地区，儿童出现了疼痛性、致残性畸形。孕妇摄入过量氟可能会毒害并改变胎儿的酶和激素系统，导致类骨质形成和矿化紊乱。开始行走时会出现膝外翻、弓形腿和军刀状胫。骨质软化、骨质疏松和骨质硬化共同作用，从幼年起就导致一系列骨骼变化。雄性激素、饮食和基因缺陷可能会加重正在快速生长的骨骼的个体反应。观察到一些提示佝偻病、甲状旁腺功能亢进和地中海贫血的影像学变化。
