Mithal A, Trivedi N, Gupta S K, Kumar S, Gupta R K
Department of Medical Endocrinology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow, India.
Skeletal Radiol. 1993;22(4):257-61. doi: 10.1007/BF00197670.
Skeletal fluorosis continues to be endemic in many parts of India. Osteosclerosis and interosseous membrane calcification have long been regarded as hallmarks of this disease. Our study showed in addition a wide variety of radiological patterns: coarse trabecular pattern, axial osteosclerosis with distal osteopenia and diffuse osteopenia. Subjects with osteopenic changes had a significantly lower dietary intake of calcium than those groups having normal radiological findings, predominant osteosclerosis or coarse trabecular pattern (p < 0.001, p < 0.01, and p < 0.01 respectively). This suggests the role of calcium intake in determining the skeletal changes in endemic fluorosis.
骨骼氟中毒在印度许多地区仍然是地方病。骨硬化和骨间膜钙化长期以来一直被视为这种疾病的标志。我们的研究还显示了多种放射学模式：粗大骨小梁模式、伴有远端骨质减少的轴向骨硬化和弥漫性骨质减少。骨质减少改变的受试者的钙饮食摄入量明显低于那些放射学表现正常、主要为骨硬化或粗大骨小梁模式的组（分别为p < 0.001、p < 0.01和p < 0.01）。这表明钙摄入量在决定地方性氟中毒骨骼变化中的作用。
