Csapo A I, Eskola J, Ruttner Z
Prostaglandins. 1980 Feb;19(2):203-11. doi: 10.1016/0090-6980(80)90020-9.
The effect of systematically delayed progesterone treatment was examined in 45 pregnant rats near term. Progesterone (P) and prostaglandin F (PGF) were measured in uterine vein plasma and uterine tissue before and during spontaneous labor or during prolonged pregnancy. Control animals exhibited the expected P-withdrawal (Pw) prior to spontaneous labor and properly timed P-treatment predictably prevented Pw and labor. However, when P was administered 11.7 +/- 2.8 hours (Mean +/- S.E.) before spontaneous labor, the animals delivered normally despite increased plasma and tissue P-levels. These observations show that P-concentration can not be equated to P-action. Thus, when high P-levels are measured near term, as in parturient women, the biological ACTION of this hormone on uterine function should be cautiously interpreted.
在45只接近足月的妊娠大鼠中研究了系统性延迟孕激素治疗的效果。在自然分娩前、分娩期间或延长妊娠期期间，测定子宫静脉血浆和子宫组织中的孕激素（P）和前列腺素F（PGF）。对照动物在自然分娩前出现预期的孕激素撤退（Pw），适时的孕激素治疗可预测地预防了Pw和分娩。然而，当在自然分娩前11.7±2.8小时（平均值±标准误）给予孕激素时，尽管血浆和组织中的孕激素水平升高，动物仍正常分娩。这些观察结果表明，孕激素浓度不能等同于孕激素作用。因此，当在接近足月时测量到高孕激素水平时，如在产妇中，应谨慎解释这种激素对子宫功能的生物学作用。
