Peluso J J, Leiper S, Steger R W
Prostaglandins. 1980 Mar;19(3):437-47. doi: 10.1016/0090-6980(80)90077-5.
The effects of a luteolytic dose of prostaglandin F2 alpha on follicular development within the ovary of pregnant mice were studied in vivo and in vitro. The results showed that 1) PGF2 alpha reduced the number of growing primary follicles both in vivo and in vitro, 2) in vitro, progesterone and LH/FSH override this effect of PGF2 alpha and 3) progesterone suppresses the rate at which primary and preantral follicles grow. It is concluded that in the ovary of the pregnant mouse, progesterone regulates the number of primary follicles which start to grow; while gonadotropins and intraovarian progesterone levels control the rate at which primary and preantral follicles develop.
在体内和体外研究了黄体溶解剂量的前列腺素F2α对妊娠小鼠卵巢内卵泡发育的影响。结果表明：1）前列腺素F2α在体内和体外均减少了生长中的初级卵泡数量；2）在体外，孕酮和促黄体生成素/促卵泡生成素可抵消前列腺素F2α的这种作用；3）孕酮抑制初级卵泡和窦前卵泡的生长速度。得出的结论是，在妊娠小鼠的卵巢中，孕酮调节开始生长的初级卵泡数量；而促性腺激素和卵巢内孕酮水平控制初级卵泡和窦前卵泡的发育速度。
