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[某些芳酰肼基二硫代甲酸的钾盐和甲酯的反应]

[Reactions of potassium salts and methyl esters of some aroylhydrazino-carbodithioic acids].

作者信息

Mazzone G, Bonina F

出版信息

Farmaco Sci. 1978 Jun;33(6):438-52.

PMID:738459
Abstract

In continuation of previous research designed to obtain compounds of pharmacological interest, the following substances were prepared, from the potassium salts (I-III) and from the methyl esters (IV-VI) of some aroylhydrazinocarbodithioic acids, derivatives of 1,3,4-oxadiazole (VII-XV), of 3-aminorhodanine (XVI-XVIII), of 1,2,4-triazole (XIX-XXI), of 7H-(1,2,4)-triazol[3,4-b] [1,3,4] thiadiazine (XXII-XXIV) and of 1,3,4-thiadiazole (XXV-XXX). The compounds have present in the molecule a nucleus and radical which have produced marked biological activity in other series of compounds. To date some of the above compounds have shown antibacterial, antimycotic and antimitotic activity.

摘要

作为先前旨在获取具有药理学意义的化合物的研究的延续,制备了以下物质,这些物质来自某些芳酰肼基二硫代甲酸的钾盐(I - III)和甲酯(IV - VI),它们是1,3,4 - 恶二唑(VII - XV)、3 - 氨基罗丹宁(XVI - XVIII)、1,2,4 - 三唑(XIX - XXI)、7H - (1,2,4) - 三唑并[3,4 - b][1,3,4]噻二嗪(XXII - XXIV)以及1,3,4 - 噻二唑(XXV - XXX)的衍生物。这些化合物的分子中存在一个核和一个基团,它们在其他系列的化合物中产生了显著的生物活性。迄今为止,上述一些化合物已显示出抗菌、抗真菌和抗有丝分裂活性。

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