• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[多种2-巯基-5-芳基-1,3,4-恶二唑的3-甲氨基衍生物的合成及抗真菌活性]

[Synthesis and antimycotic activity of 3-methylamino derivatives of various 2-mercapto-5-aryl-1,3,4-oxadiazoles].

作者信息

Mazzone G, Bonina F

出版信息

Farmaco Sci. 1979 May;34(5):390-402.

PMID:554792
Abstract

In continuation of previous work designed to obtain derivatives of 2-mercapto-1,3,4-oxadiazole of possible biological interest, the Mannich bases (III - XXX) were prepared. The compounds prepared bear at position 5, with respect to the oxadiazole nucleus, 3,4,5-trimethoxy and 3,4-dihydroxymethylenephenyl radicals which have proved of interest in other series of derivatives. The antimycotic activity of the compounds is reported.

摘要

作为之前旨在获得可能具有生物学意义的2-巯基-1,3,4-恶二唑衍生物的工作的延续，制备了曼尼希碱（III - XXX）。所制备的化合物在相对于恶二唑核的5位带有3,4,5-三甲氧基和3,4-二羟基亚甲基苯基自由基，这些自由基在其他系列的衍生物中已被证明具有研究价值。报道了这些化合物的抗真菌活性。

相似文献

1
[Synthesis and antimycotic activity of 3-methylamino derivatives of various 2-mercapto-5-aryl-1,3,4-oxadiazoles].[多种2-巯基-5-芳基-1,3,4-恶二唑的3-甲氨基衍生物的合成及抗真菌活性]
Farmaco Sci. 1979 May;34(5):390-402.
2
[Synthesis and pharmacological study of various 2-(alkylaminoalkyl)mercapto-5-aryl-1,3,4-oxadiazoles].[多种2-(烷基氨基烷基)巯基-5-芳基-1,3,4-恶二唑的合成及药理研究]
Farmaco Sci. 1977 Jun;32(6):414-29.
3
[Reactions of potassium salts and methyl esters of some aroylhydrazino-carbodithioic acids].[某些芳酰肼基二硫代甲酸的钾盐和甲酯的反应]
Farmaco Sci. 1978 Jun;33(6):438-52.
4
Synthesis and antimicrobial activity of some novel oxadiazole derivatives.一些新型恶二唑衍生物的合成与抗菌活性
Acta Pol Pharm. 2008 Jul-Aug;65(4):441-7.
5
Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.2-(4,5-二氢异恶唑-5-基)-1,3,4-恶二唑的合成与生物活性
Bioorg Med Chem Lett. 2009 Oct 1;19(19):5796-8. doi: 10.1016/j.bmcl.2009.07.139. Epub 2009 Aug 6.
6
Studies on the synthesis and biological activity of 3-arylaminomethyl-5-(3-pyridyl)-1,3,4-oxadiazole-2-thione derivatives.3-芳基氨基甲基-5-(3-吡啶基)-1,3,4-恶二唑-2-硫酮衍生物的合成及生物活性研究
Boll Chim Farm. 2001 Jul-Aug;140(4):228-32.
7
[Aminoethyl derivatives of various 5-aryl-1,3,4-oxadiazol-2-ones: synthesis and pharmacological activity].[各种5-芳基-1,3,4-恶二唑-2-酮的氨乙基衍生物：合成与药理活性]
Farmaco Sci. 1980 Jun;35(6):527-34.
8
[Reactivity of 3-aryl-4-amino-5-mercapto-4H-1,2,4-triazoles: synthesis and biological evaluation of 3,6-diaryl derivatives of 7H-1,2,4-thiazole[3,4-b][1,3,4]thiadiazines, of 3-aryl-4-amino-5-carboxymethylthio-4H-1,2,4-triazoles].[3-芳基-4-氨基-5-巯基-4H-1,2,4-三唑的反应活性：7H-1,2,4-噻唑并[3,4-b][1,3,4]噻二嗪的3,6-二芳基衍生物、3-芳基-4-氨基-5-羧甲基硫基-4H-1,2,4-三唑的合成与生物学评价]
Farmaco Sci. 1987 Jul;42(7):525-39.
9
Synthesis and biological evaluation of some 5-aryl-2-amino-1,3,4-oxa(thia)diazoles.某些5-芳基-2-氨基-1,3,4-恶（硫）二唑的合成与生物学评价
Farmaco Sci. 1982 Oct;37(10):685-700.
10
Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives.双-1,3,4-恶二唑衍生物的合成、抗菌、抗真菌及遗传毒性活性
Pol J Pharmacol. 2002 Jan-Feb;54(1):55-9.

引用本文的文献

1
Synthesis and antimicrobial evaluation of some new oxadiazoles derived from phenylpropionohydrazides.一些源自苯丙酰肼的新型恶二唑的合成与抗菌活性评价
Molecules. 2009 May 20;14(5):1898-903. doi: 10.3390/molecules14051898.