The relative effectiveness of some chelating agents in acute copper intoxication in the mouse.

The relative efficacy of 9 chelating agents in offsetting the acute toxicity of ip copper sulfate has been determined. Included in this group are almost all of the compounds which have been used in, or suggested for use in human cases of acute or chronic copper toxicity. Under the conditions used, sodium 2,3-dimercapto-1-propanesulfonate is by far the most effective antidote of the compounds examined.