Bohman T, Myren J, Flaten O, Schrumpf E
Scand J Gastroenterol. 1980;15(2):177-82. doi: 10.3109/00365528009181451.
In the present study a comparison was made of the effect of increasing doses of trimipramine (0.05, 0.10, 0.20, 0.40 mg/kg/h), atropine (7, 14, 21, 28 microgram/kg/h), and cimetidine (0.3, 0.6, 1.2, 2.4 mg/kg/h) on the gastric secretion stimulated by 3 microgram/kg/h of histamine dihydrochloride as continuous infusion, each dose step lasting 30 min. In nine healthy individuals it was found that trimipramine had a stimulating effect on the volume and output of acid during one of eight 15-min periods. The largest dose of atropine caused a reduction of the volume and acid output by 68% and 77%, respectively, whereas cimetidine reduced the volume by 74% and the acid output by 89% during the last five 15-min periods, thus having the most pronounced effect. The study may suggest that the healing effect of trimipramine on peptid ulcer is not linked to the effect on submaximal histamine-stimulated secretion and that a different mechanism of action is probably present for the effect of trimipramine, compared with atropine and cimetidine, on the gastric secretion.
在本研究中，对递增剂量的曲米帕明（0.05、0.10、0.20、0.40毫克/千克/小时）、阿托品（7、14、21、28微克/千克/小时）和西咪替丁（0.3、0.6、1.2、2.4毫克/千克/小时），以连续输注3微克/千克/小时盐酸组胺刺激胃液分泌的影响进行了比较，每个剂量阶段持续30分钟。在9名健康个体中发现，曲米帕明在八个15分钟时间段中的一个时间段内对胃酸的分泌量和分泌率有刺激作用。最大剂量的阿托品分别使分泌量和胃酸分泌率降低了68%和77%，而西咪替丁在最后五个15分钟时间段内使分泌量降低了74%，胃酸分泌率降低了89%，因此具有最显著的效果。该研究可能表明，曲米帕明对消化性溃疡的愈合作用与对次最大组胺刺激分泌的影响无关，并且与阿托品和西咪替丁相比，曲米帕明对胃液分泌的作用可能存在不同的作用机制。
