组胺输注后人体血清胰多肽浓度及西咪替丁、三甲丙咪嗪和阿托品的影响
Serum concentration of pancreatic polypeptide after infusion of histamine and the effect of cimetidine, trimipramine, and atropine in man.
作者信息
Flaten O, Bohman T, Myren J
出版信息
Scand J Gastroenterol. 1981;16(8):989-91. doi: 10.3109/00365528109181016.
Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.
对8名人体受试者静脉注射组胺后，血清中胰多肽（PP）浓度从14.8（7.2 - 29.3）pM显著升高至27.5（9.6 - 39.3）pM，然后降至基础水平。当除组胺外还给予曲米帕明或西咪替丁时，这种组胺诱导的PP释放没有改变。这种PP释放不能通过组胺受体机制介导，并且由于阿托品可阻止这种PP释放，我们得出结论，组胺后PP的释放反映了胆碱能刺激。
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