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子宫内先天性膈疝的矫正。I. 模型:胸腔内气囊导致致命性肺发育不全。

Correction of congenital diaphragmatic hernia in utero. I. The model: intrathoracic balloon produces fatal pulmonary hypoplasia.

作者信息

Harrison M R, Jester J A, Ross N A

出版信息

Surgery. 1980 Jul;88(1):174-82.

PMID:7385020
Abstract

A conical silicone rubber balloon was placed in the left hemithorax of fetal lambs and progressively inflated through an exteriorized catheter over the last trimester. Newborn lambs died of severe respiratory insufficiency, despite maximal resuscitation. The lungs were markedly hypoplastic with greatly reduced parenchymal mass and air capacity. This model of a progressively enlarging intrathoracic mass which produces severe pulmonary hypoplasia and fatal respiratory insufficiency simulates the pathophysiology of congenital diaphragmatic hernia in human neonates.

摘要

将一个圆锥形硅橡胶气球置于胎羊的左半胸,并在妊娠晚期通过一根外置导管逐渐充气。尽管进行了最大程度的复苏,新生羔羊仍死于严重的呼吸功能不全。肺部明显发育不全,实质质量和空气容量大大降低。这种逐渐增大的胸腔内肿块导致严重肺发育不全和致命呼吸功能不全的模型模拟了人类新生儿先天性膈疝的病理生理学。

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