促性腺激素与黄体膜的相互作用。VII. 人绒毛膜促性腺激素结合及腺苷酸环化酶活性与兔黄体质膜的关联。

Interations of gonadotropins with corpus luteum membranes. VII. Association of hCG-binding and adenylate cyclase activities with rabbit corpus luteum plasma-membranes.

作者信息

Bramley T A, Ryan R J

出版信息

Mol Cell Endocrinol. 1978 Dec;12(3):319-25. doi: 10.1016/0303-7207(78)90090-4.

Abstract

Previous studies with rat luteal cell plasma membranes indicated a dissociation of hCG binding sites and adenylate cyclase activity. The hormone binding sites were associated with a light membrane (d 1.13) fraction derived from the microvillous surface while the cyclase enzyme was associated with a heavy membrane (d 1.17) fraction derived from the basolateral surface of the cell. In this study of plasma membranes from 8-day pseudopregnant rabbit corpora lutea both hCG binding and adenylate cyclase activity were associated with a light membrane (d 1.13) fraction. No heavy membrane material was detected.

摘要

先前对大鼠黄体细胞质膜的研究表明，人绒毛膜促性腺激素（hCG）结合位点与腺苷酸环化酶活性解离。激素结合位点与源自微绒毛表面的轻膜（密度1.13）组分相关，而环化酶与源自细胞基底外侧表面的重膜（密度1.17）组分相关。在这项对8天假孕兔黄体细胞质膜的研究中，hCG结合和腺苷酸环化酶活性均与轻膜（密度1.13）组分相关。未检测到重膜物质。