镉对雄性和雌性大鼠中苯巴比妥诱导肝微粒体单加氧酶作用的性别相关差异。
Sex-related differences in the effect of cadmium on the induction of hepatic microsomal monooxygenases by phenobarbital in male and female rats.
作者信息
Pence D H, Schnell R C
出版信息
Toxicol Lett. 1980 Apr;5(5):333-8. doi: 10.1016/0378-4274(80)90034-x.
PMID:7385254
Abstract
3 days following an intraperitoneal injection of cadmium [Cd] (2.0 mg Cd/kg) an inhibition in hepatic microsomal drug metabolism for ethylmorphine and aniline was observed in male rats. Such treatment in female rats only inhibited metabolism of aniline. Following treatment with phenobarbital (50 mg/kg, i.p., for 4 days), the metabolism of both substrates was induced in rats of both sexes. In male rats, but not in female rats, Cd blocked the inducing action of phenobarbital.
摘要
腹腔注射镉Cd3天后，在雄性大鼠中观察到肝微粒体对乙基吗啡和苯胺的药物代谢受到抑制。对雌性大鼠进行这种处理仅抑制了苯胺的代谢。用苯巴比妥(50毫克/千克，腹腔注射，共4天)处理后，两种性别的大鼠中两种底物的代谢均被诱导。在雄性大鼠中，而非雌性大鼠中，镉阻断了苯巴比妥的诱导作用。
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