Ichikawa Y, Takaya M, Arimori S
Tokai J Exp Clin Med. 1980 Jan;5(1):83-90.
Antibody-dependent cell-mediated cytotoxicity (ADCC) by peripheral blood mononuclear cells in patients with Sjögren's syndrome (SjS) was estimated with special reference to differentiation from phagocytic activity caused by phagocytes. There was no significant difference in ADCC activity of peripheral blood lymphocytes (phagocyte-depleted lymphocyte fraction) between patients with SjS and normal persons. Higher ADCC activity of the crude lymphocyte fraction (CLF), however, was demonstrated in patients with SjS than in normal persons. It was proved that increased ADCC activity of CLF in patients with SjS resulted from reduced erythro-phagocytic activity of contaminating monocytes in this fraction.
对干燥综合征（SjS）患者外周血单个核细胞的抗体依赖性细胞介导的细胞毒性（ADCC）进行了评估，并特别参考了其与吞噬细胞引起的吞噬活性的差异。SjS患者和正常人外周血淋巴细胞（去除吞噬细胞的淋巴细胞部分）的ADCC活性没有显著差异。然而，SjS患者粗淋巴细胞部分（CLF）的ADCC活性高于正常人。已证实，SjS患者CLF的ADCC活性增加是由于该部分中污染单核细胞的红细胞吞噬活性降低所致。
