McGill P E, Svensson E O
Trans R Soc Trop Med Hyg. 1980;74(2):197-200. doi: 10.1016/0035-9203(80)90244-8.
In 1970, before iodized salt was introduced as prophylaxis against goitre in Kenya, we performed quantitative studies of iodine metabolism in 81 African subjects living in the highland provinces. Iodine deficiency was detected in those with and without goitre, a result expected in view of the known prevalences of endemic goitre in these regions. Iodine deficiency was more severe and prevalent in those with goitre. Unexpectedly, we found those with goitre had a significant defect in the utilization of iodine by the thyroid gland. We argue that this defect is probably caused by an environmental factor. If adequate iodine prophylaxis is followed by a significant decline in the goitre rate, our finding is of theoretical interest only. It would assume practical importance if a significant goitre problem remained following improvement in iodine nutrition. We have decided to publish these findings now because of the disappointing results of iodine prophylaxis to date.
1970年，在肯尼亚引入碘盐作为预防甲状腺肿的措施之前，我们对生活在高原省份的81名非洲受试者进行了碘代谢的定量研究。无论有无甲状腺肿，均检测到碘缺乏，鉴于这些地区已知的地方性甲状腺肿患病率，这一结果在意料之中。碘缺乏在患有甲状腺肿的人群中更为严重和普遍。出乎意料的是，我们发现患有甲状腺肿的人甲状腺对碘的利用存在明显缺陷。我们认为这种缺陷可能是由环境因素引起的。如果充足的碘预防措施能使甲状腺肿发病率显著下降，我们的发现仅具有理论意义。如果碘营养改善后仍存在严重的甲状腺肿问题，它将具有实际重要性。由于迄今为止碘预防措施的结果令人失望，我们决定现在公布这些发现。
