[Diurnal rhythm of mitoses and rate of cell renewal in rat tissues following adrenalectomy].

Numbers of mitoses and of colchicine mitoses, and the duration of mitosis in corneal and tongue epithelium as well as in hepatocytes of intact and adrenalectomized rats have been studied in dynamics within 24 hours. In the control animals, the 24 hours rhythm of mitotic activity and the duration of mitosis were established. The length of mitosis falls during the high rate mitotic activity to increase when the number of dividing cells is reduced. Adrenalectomy results in decreasing the amplitude of mitotic activity fluctuations and in diminishing the amount cells entering mitosis during the 24 hours period. The rate of physiological regeneration in tissues of adrenalectomized animals is reduced. Different sensibilities of investigated tissues to adrenal cortex hormones deficiency have been revealed.