[Circadian rhythm of mitoses and number of cells synthesizing DNA following adrenalectomy in mice].

The diurnal changes in the number of mitoses and DNA-synthesizing cells were studied in intact and adrenalectomized mice. In the corneal epithelium of adrenalectomized mice the diurnal rhythm of DNA-synthesizing cells became biphasic, and the variation amplitude of the 24-hour mitotic activity was sharply intensified. In the liver the diurnal rhythm of DNA-synthesizing cells was similar in the intact and the operated on mice; as to the mitotic rhythm - it became biphasic in the operated on animals. Thus, adrenalectomy deranged the phasic structure of the mitotic and DNA-synthesizing rhythms in the tissues under study and led to dissociation in the entrance of cells into the DNA-synthesis and mitosis.