Garkavi L Kh, Kvakina E B, Mulatova A K, Shikhliarova A I
Vopr Onkol. 1980;26(6):48-53.
The antitumor effect of common nonspecific adaptation reactions of training and activation, obtained by small doses of adrenaline, was studied in the experiments on white rats with sarcoma 45,3,4-benz/a/-pyrene induced tumors and Biskind ovary tumor. Total resorption of the tumor was noted in all cases (55 rats), in which histological investigation of the thymus, lymph nodes, endocrinous glands and white cell count evidenced the development of the activation reaction, while with the training reaction there was only some retardation of tumor growth (51 rats). When it proved impossible to overcome a "chronic" tumor stress (45 rats), no antitumor effect was gained. Thus, the reactions of training and activation obtained by small doses of adrenaline (at high level of the organism reactivity) were found to increase the antitumor reaction of the organism.
在对患有肉瘤45、3,4-苯并[a]芘诱导肿瘤和比斯基德卵巢肿瘤的白鼠进行的实验中，研究了通过小剂量肾上腺素获得的训练和激活的常见非特异性适应反应的抗肿瘤作用。在所有病例（55只大鼠）中均观察到肿瘤完全消退，其中对胸腺、淋巴结、内分泌腺的组织学检查以及白细胞计数证明激活反应已经发生，而在训练反应中，肿瘤生长仅出现了一些迟缓（51只大鼠）。当证明无法克服“慢性”肿瘤应激时（45只大鼠），未获得抗肿瘤效果。因此，发现通过小剂量肾上腺素获得的训练和激活反应（在机体反应性较高水平时）可增强机体的抗肿瘤反应。
