Garkavi L Kh, Kvakina E B, Mulatova A K, Taras'iants F M
Vopr Onkol. 1981;27(7):61-6.
The susceptibility of tumor tissue to therapeutic and smaller doses of chemotherapeutic drugs was assessed on the basis of SH-group inhibition in vitro. As therapeutic dose was decreased, rhythmic changes of tumor susceptibility were observed. In the experiments on tumor-bearing rats, the small dose of chemotherapeutic agent, which in preliminary in vitro experiments proved to be as effective as therapeutic one (1/5 therapeutic dose), was found to cause the same suppression of tumor growth. However, it did not induce leukopenia, lymphopenia, thymus involution or any other manifestations of stress which followed multiple injections of therapeutic doses. The white blood cell and thymus indices in rats, which received the small dose, suggest the development of reactions of training and activation which increase the nonspecific resistance of organism.
基于体外SH基团抑制作用评估了肿瘤组织对治疗剂量及更小剂量化疗药物的敏感性。随着治疗剂量降低，观察到肿瘤敏感性的节律性变化。在荷瘤大鼠实验中，发现小剂量化疗药物（在初步体外实验中证明与治疗剂量一样有效，为治疗剂量的1/5）可引起相同程度的肿瘤生长抑制。然而，它并未诱发白细胞减少、淋巴细胞减少、胸腺萎缩或多次注射治疗剂量后出现的任何其他应激表现。接受小剂量药物的大鼠的白细胞和胸腺指标表明，机体产生了训练和激活反应，从而增强了机体的非特异性抵抗力。
