Tsitolovskiĭ L E, Tsaturian O I, Gus'kov S V
Zh Vyssh Nerv Deiat Im I P Pavlova. 1980 Jan-Feb;30(1):177-84.
The elaboration of habituation to repeated tactile stimuli was studied in snail (Helix pomatia) by means of intracellular recording of the neuronal activity and microionophoresis of acetylcholine (ACh). Light or a stronger tactile stimulation served as extrastimulus. The elaboration of habituation was accompanied by a rise in the threshold of action potentials (APs) generation, evoked by the habitual stimulus, and by a lowering of the threshold of APs elicited by the extrastimulus. Prior to the habituation neuronal responses to tactile or photic stimuli did not change against the ACh background. After habituation was elaborated the ACh administration led to disinhibition of responses to the habitual stimulus (in particular, the AP threshold became lower), and to a decrease in responses to the extrastimulus (AP threshold rose). It is assumed that hibituation changes the chemical responses caused in the neurone by the activation of both the pool of synapses, corresponding to the habitual stimulus, and the pool of synapses corresponding to the extrastimulus. These changes, however, are of a qualitatively different character.
通过对蜗牛（苹果螺）神经元活动进行细胞内记录以及对乙酰胆碱（ACh）进行微量离子电泳，研究了对重复触觉刺激的习惯化形成过程。轻度或较强的触觉刺激作为额外刺激。习惯化的形成伴随着由习惯刺激诱发的动作电位（AP）产生阈值的升高，以及由额外刺激引发的AP阈值的降低。在习惯化之前，神经元对触觉或光刺激的反应在ACh背景下没有变化。习惯化形成后，给予ACh导致对习惯刺激的反应去抑制（特别是AP阈值变低），以及对额外刺激的反应减少（AP阈值升高）。据推测，习惯化改变了由对应习惯刺激的突触池和对应额外刺激的突触池激活所引起的神经元化学反应。然而，这些变化具有质的不同。
