Zhadina S D, Vinogradova O S, Bragin A G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1980 Mar-Apr;30(2):392-7.
The activity of neurones of the medial septal nucleus was recorded in guinea pig brain slices in vitro during injection of acetylcholine (ACh) and glutamate (Gl) into the incubating medium. Gl produced stereotype initial activating influence, but in many units (12 out of 31) the activating phase was followed by a decrease of discharge frequency and an increase of spike amplitude. The effects of ACh depended upon the type of spontaneous neuronal activity. In units with a regular pacemaker-like activity it produced an increase of discharge frequency with slow, gradual onset and offset of response. In neurones with an irregular and burst activity ACh application evoked rhythmic bursts or increased their regularity with variable changes of the mean frequency in different units. The two functional types of the units in medial septum are discussed.
在豚鼠脑片的体外实验中，向孵育培养基中注射乙酰胆碱（ACh）和谷氨酸（Gl）时，记录内侧隔核神经元的活动。Gl产生刻板的初始激活影响，但在许多单位（31个中的12个）中，激活阶段之后是放电频率降低和峰电位幅度增加。ACh的作用取决于神经元自发活动的类型。在具有规则起搏器样活动的单位中，它使放电频率增加，反应的起始和结束缓慢且逐渐。在具有不规则和爆发性活动的神经元中，应用ACh诱发节律性爆发或增加其规律性，不同单位的平均频率有不同变化。讨论了内侧隔核中两种功能类型的单位。
