Zhadina S D, Vinogradova O S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1982 Mar-Apr;32(2):319-26.
Effects of Ach, NE and 5HT, introduced into the bath medium, were investigated in 75 units recorded extracellularly in slices of the guinea pig septum. Equally high reactivity to the all three substances was observed (86-88% of reactive units). Ach evoked slowly developing moderate increase of spontaneous activity in 63% of the units; in 24% it enhanced, accelerated, or evoked rhythmic bursts (1-3,5 per s). NE evoked higher and rapidly developing activation in 73% of the units; 5HT increased or decreased the level of activity in equal proportions of the cells (45% each). Both NE and 5HT neither provoked nor intensified rhythmic burst activity. Activatory and inhibitory effects of NE, 5HT and Ach were not blocked in the medium with high Mg2+ concentration. Burst activity disappeared in this condition in some units, but was preserved in the others. It is concluded that in some of the septal units transmitter substances modulate the activity of endogenous pacemaker mechanism.
在豚鼠中隔切片细胞外记录的75个单位中，研究了引入浴液介质中的乙酰胆碱（Ach）、去甲肾上腺素（NE）和5-羟色胺（5HT）的作用。观察到对所有这三种物质具有同样高的反应性（反应单位的86 - 88%）。Ach在63%的单位中引起自发活动缓慢发展的适度增加；在24%的单位中它增强、加速或引发节律性爆发（每秒1 - 3.5次）。NE在73%的单位中引起更高且快速发展的激活；5HT在同等比例的细胞中（各45%）增加或降低活动水平。NE和5HT既不引发也不增强节律性爆发活动。在高镁离子浓度的介质中，NE、5HT和Ach的激活和抑制作用未被阻断。在这种情况下，一些单位的爆发活动消失，但在其他单位中得以保留。得出的结论是，在一些中隔单位中，递质物质调节内源性起搏器机制的活动。
