Jessen K
Acta Anaesthesiol Scand. 1980 Apr;24(2):144-50. doi: 10.1111/j.1399-6576.1980.tb01523.x.
By a standardized exposure to cold air under simultaneous vasodilation, it was possible to elucidate the chemical factors responsible for heat production independent of muscular activity in seven patients with thyrotoxicosis and in nine patients with hypothyroidism. The results showed that hyperthryroid patients have a thermoregulatory reserve equal to normal persons, as they were able to increase their oxygen consumption significantly by an average of 0.035 mmol . kg-1 . min-1 (16%) (range: 0.014--0.064). The plasma concentration of non-esterified fatty acids (NEFA) increased significantly by an average of 0.675 mmol/l (64%) (range: 0.015--2.220). The hypothyroid patients also increased their oxygen consumption significantly by an average of 0.032 mmol . kg-1 . min-1 (30) (range: -0.016--0.066), but in this group the normal fat mobilization was inhibited as no rise in plasma NEFA was seen. Administration of exogenous thyroxine restored thermoregulation to the level and pattern seen in normothyroid persons, as the increase in plasma NEFA after treatment was on average 0.483 nnol/l (192%) (range: 0.342--0.733).
通过在血管舒张的同时对冷空气进行标准化暴露，得以阐明七名甲状腺毒症患者和九名甲状腺功能减退患者中与肌肉活动无关的产热化学因素。结果显示，甲状腺功能亢进患者具有与正常人相当的体温调节储备，因为他们能够将耗氧量显著增加，平均增加0.035 mmol·kg⁻¹·min⁻¹（16%）（范围：0.014 - 0.064）。非酯化脂肪酸（NEFA）的血浆浓度平均显著增加0.675 mmol/l（64%）（范围：0.015 - 2.220）。甲状腺功能减退患者的耗氧量也显著增加，平均增加0.032 mmol·kg⁻¹·min⁻¹（30）（范围：-0.016 - 0.066），但在该组中，正常的脂肪动员受到抑制，因为未观察到血浆NEFA升高。给予外源性甲状腺素可使体温调节恢复到甲状腺功能正常者的水平和模式，因为治疗后血浆NEFA的增加平均为0.483 nnol/l（192%）（范围：0.342 - 0.733）。
