Raz A, Erman A
Adv Prostaglandin Thromboxane Res. 1980;6:231-4.
The divalent cations Ca2+, Mg2+, Co2+, Mn2+, Sr2+, and Ba2+ were compared for their stimulatory or inhibitory effect on PG formation in rabbit kidney medulla slices. Calcium, manganese, and strontium ions stimulated PG generation up to 3- to 5-fold in a time- and dose-dependent manner (Ca2+ greater than Mn2+ approximately Sr2+) while the magnesium and cobalt ions were without significant effects. Stimulatory effects of Ca2+, Mn2+, and Sr2+ on the medullary generation of PGE2 was found to correlate with their stimulatory effects on the release of AA and LL acids from tissue lipids. The release of other fatty acids was unaffected. As both AA and LL acids are predominantly found in the 2-position of phospholipids, the stimulation by these cations appears to be mediated via stimulation of phospholipase A2 activity.
比较了二价阳离子Ca2+、Mg2+、Co2+、Mn2+、Sr2+和Ba2+对兔肾髓质切片中前列腺素（PG）生成的刺激或抑制作用。钙、锰和锶离子以时间和剂量依赖性方式刺激PG生成，最高可达3至5倍（Ca2+>Mn2+≈Sr2+），而镁和钴离子则无显著影响。发现Ca2+、Mn2+和Sr2+对髓质中PGE2生成的刺激作用与其对组织脂质中花生四烯酸（AA）和亚油酸（LL酸）释放的刺激作用相关。其他脂肪酸的释放未受影响。由于AA和LL酸主要存在于磷脂的2位，这些阳离子的刺激作用似乎是通过刺激磷脂酶A2活性介导的。
