Cottney J, Bruin J, Lewis A J
Agents Actions. 1980 Apr;10(1 Pt 2):48-56. doi: 10.1007/BF02024178.
The effects of administering drugs 2 days after antigen sensitization in a combined model of delayed type hypersensitivity (DTH) and humoral immunity (HI) in the mouse are described and compared with a previous study in which drugs were administered prior to sensitization using the same model. Low doses of cyclophosphamide (CY) administered after antigen sensitization were found to enhance DTH to methylated bovine serum albumin (MBSA). In addition, high doses of this drug suppressed DTH for 3 days after challenge, and then enhanced the response for a further 5 days. The HI response to sheep red blood cells (SRBC) was simultaneously suppressed by a range of CY doses. A number of different drug types demonstrated a similar pattern of dose-dependent DTH effects. However, unlike the previous study DTH enhancement was not confined to the alkylating agents. Either DTH enhancement or suppression was also observed after treatment with a number of other drugs. HI was suppressed by several drugs, in particular by a number of alkylating agents and anti-metabolites. Selective effects on one or other limbs of the immune response were observed. The mode(s) of action of drugs active in the present study are uncertain but possible explanations are discussed in terms of the elimination and subsequent recovery of specific cell populations.
本文描述了在小鼠迟发型超敏反应（DTH）和体液免疫（HI）联合模型中，抗原致敏2天后给药的效果，并与之前在同一模型中致敏前给药的研究进行了比较。发现在抗原致敏后给予低剂量的环磷酰胺（CY）可增强对甲基化牛血清白蛋白（MBSA）的DTH反应。此外，高剂量的该药物在激发后3天抑制DTH反应，随后在接下来的5天增强反应。对绵羊红细胞（SRBC）的HI反应同时被一系列CY剂量所抑制。许多不同类型的药物表现出类似的剂量依赖性DTH效应模式。然而，与之前的研究不同，DTH增强并不局限于烷化剂。在用多种其他药物治疗后也观察到DTH增强或抑制。HI被几种药物抑制，特别是一些烷化剂和抗代谢物。观察到对免疫反应的一个或另一个分支的选择性作用。本研究中具有活性的药物的作用方式尚不确定，但根据特定细胞群的消除和随后的恢复对可能的解释进行了讨论。
