Cottney J, Bruin J, Lewis A J
Agents Actions. 1980 Sep;10(4):378-88. doi: 10.1007/BF01971444.
A model has been developed in the mouse in which methylated bovine serum albumin (MBSA) and sheep red blood cells have been used to produce delayed type hypersensitivity (DTH) and humoral immunity (HI), respectively. The time course between antigen sensitization and challenge was chosen such that cyclophosphamide (CY), administered prior to sensitization, produced DTH enhancement and also produced suppression of HI when administered at high doses. A number of other drugs have been examined in this model but only CY-like drugs, viz. alkylating agents, produced similar DTH enhancement. DTH was suppressed in a few cases. The HI response was enhanced or suppressed by a number of unrelated drugs. CY was the only alkylating agent to suppress the antibody titre. The mechanisms for these drug effects are uncertain. However, a number of drugs elicit effects on either DTH or HI which suggests there is selective removal of certain cell populations rather than non-specific cytotoxicity. Possible theories for the effects observed are discussed. These studies also suggest that CY possesses unique properties in this particular model.
已在小鼠中建立了一种模型，其中甲基化牛血清白蛋白（MBSA）和绵羊红细胞分别用于产生迟发型超敏反应（DTH）和体液免疫（HI）。选择抗原致敏和激发之间的时间进程，使得在致敏前给予环磷酰胺（CY）可增强DTH，并且在高剂量给药时也可抑制HI。已在该模型中检测了许多其他药物，但只有类似CY的药物，即烷基化剂，产生了类似的DTH增强作用。在少数情况下DTH受到抑制。HI反应被许多无关药物增强或抑制。CY是唯一能抑制抗体滴度的烷基化剂。这些药物作用的机制尚不确定。然而，许多药物对DTH或HI有影响，这表明存在某些细胞群的选择性清除，而不是非特异性细胞毒性。讨论了观察到的效应的可能理论。这些研究还表明CY在这个特定模型中具有独特的性质。
