Rogers E L, Douglass W, Russell R M, Bushman L, Hubbard T B, Iber F L
Am J Clin Nutr. 1980 Jun;33(6):1208-14. doi: 10.1093/ajcn/33.6.1208.
Significant vitamin A, E, or 25-hydroxy D deficiency occurred in 76% of 40 patients studied up to 6 years after jejunoileal bypass surgery for morbid obesity. Vitamin A was significantly lower in those who had lost 30% of their initial weight than in those who had lost less weight; however, there was no correlation of vitamin A, E, or D levels, time elapsed since surgery, or with daily intake of vitamins as subnormal values were found despite multivitamin supplementation and consumption of twice the recommended daily allowance of vitamin A. Functional derangement of retinal adaptation to darkness secondary to vitamin A deficiency was found in four of nine stable, healthy patients studied at least 18 months after surgery. There was no linear relationship between vitamin A levels and dark adapted final thresholds or with serum albumin, prothrombin time, or degree of steatorrhea. Three patients with abnormal adapted final thresholds were treated with vitamin A. Total daily intake of up to 65,000 IU of vitamin A daily for several months resulted in normalization of function in all.
在40例因病态肥胖接受空回肠旁路手术的患者中，有76%在术后长达6年的时间里出现了显著的维生素A、E或25-羟基维生素D缺乏。体重减轻了初始体重30%的患者，其维生素A水平显著低于体重减轻较少的患者；然而，维生素A、E或D水平与术后时间或维生素每日摄入量之间并无关联，尽管补充了多种维生素且维生素A的摄入量是推荐每日摄入量的两倍，但仍发现这些维生素水平低于正常。在术后至少18个月接受研究的9例稳定、健康患者中，有4例出现了因维生素A缺乏导致的视网膜暗适应功能紊乱。维生素A水平与暗适应最终阈值之间，或与血清白蛋白、凝血酶原时间或脂肪泻程度之间均无线性关系。3例暗适应最终阈值异常的患者接受了维生素A治疗。连续数月每日摄入高达65,000国际单位的维生素A，最终所有患者的功能均恢复正常。
