Godala Małgorzata, Materek-Kuśmierkiewicz Izabela, Moczulski Dariusz, Rutkowski Maciej, Szatko Franciszek, Gaszyńska Ewelina, Tokarski Sławomir, Kowalski Jan
Department of Nutrition and Epidemiology, Chair of Hygiene and Epidemiology, Medical University of Łódz, Poland.
Department of Internal Medicine and Nephrodiabetology, Chair of Internal Diseases and Cardiology, Medical University of Łódz, Poland.
Adv Clin Exp Med. 2017 Jul;26(4):581-586. doi: 10.17219/acem/62453.
The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon. Vitamin D deficiency is also associated with cardiovascular diseases.
The aim of the study was to assess the risk of vitamin A, C, E and D deficit in the plasma of metabolic syndrome (MS) patients.
The study included 191 patients with MS and 98 subjects without MS. Loglinear analysis was used in the assessment of mutual interactions between the vitamin concentration and the analysis of classification by ROC curves to predict the frequency of vitamin deficiency in MS patients.
A correlation was found between the plasma level of vitamins in the group of MS patients. Vitamin A concentration correlated with that of vitamin C (r = 0.51, p = 0.0000), vitamin D (r = 0.49, p = 0.0000) and E (r = 0.32, p = 0.0001). The plasma level of vitamin D correlated with the level of vitamin E (r = 0.46, p = 0.00000) and vitamin C (r = 0.37, p = 0.0000). Regression analysis showed a correlation between the concentration of the tested vitamins in patients with MS. Interactions were observed between vitamins C and A and between C and D. HDL cholesterol level was lower in patients with vitamin A deficiency compared to patients with its normal level.
The plasma levels of vitamin A, C, E and D were significantly lower in patients with MS than in healthy subjects and they mutually correlated with each other. The normalization of glucose and HDL level may contribute to the regulation of the concentration of vitamin A in patients with MS.
肥胖或糖尿病等代谢性疾病发病率不断上升，已成为主要的公共卫生问题。除其他风险因素外，由活性氧引发的氧化应激增加会导致细胞发生氧化损伤，被认为是这些疾病的潜在病因。维生素A、C和E被列为对抗这一现象的非酶机制。维生素D缺乏也与心血管疾病有关。
本研究旨在评估代谢综合征（MS）患者血浆中维生素A、C、E和D缺乏的风险。
本研究纳入了191例MS患者和98例非MS受试者。采用对数线性分析评估维生素浓度之间的相互作用，并通过ROC曲线分析进行分类，以预测MS患者维生素缺乏的频率。
MS患者组血浆维生素水平之间存在相关性。维生素A浓度与维生素C（r = 0.51，p = 0.0000）、维生素D（r = 0.49，p = 0.0000）和维生素E（r = 0.32，p = 0.0001）浓度相关。维生素D血浆水平与维生素E水平（r = 0.46，p = 0.00000）和维生素C水平（r = 0.37，p = 0.0000）相关。回归分析显示MS患者中所检测维生素的浓度之间存在相关性。观察到维生素C与A之间以及C与D之间存在相互作用。维生素A缺乏患者的高密度脂蛋白胆固醇水平低于维生素A水平正常的患者。
MS患者血浆中维生素A、C、E和D水平显著低于健康受试者，且它们之间相互关联。血糖和高密度脂蛋白水平的正常化可能有助于调节MS患者体内维生素A的浓度。
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