Cumulative sum control charts for admixture quality control.

The use of cumulative sum control charts as a means of monitoring the sterility of i.v. admixtures produced by a centralized service is discussed. To create a sum control chart, acceptable and rejectable quality levels must be determined. Frequency of sampling will responsiveness and can be varied to affect the length of time necessary to detect an unacceptable shift in product quality. Cumulative sum control charts allow monitoring to be carried out on a cost versus benefit basis, and can be used to provide a basis for action on production of existing product and to maintain or improve product quality in the future.