Children at risk for schizophrenia.

Etiological factors in the transmission of schizophrenia are reviewed; models include psychogenic, genetic, gene/environment interaction. Investigation of premorbid history is discussed employing retrospective, follow-back, follow-up, and prospective studies. Certain symptom clusters (attentional and cognitive deficits, poor socialization, withdrawal) in genetically predisposed individuals may predict schizophrenia. Stress-reducing therapeutic environments are proposed.